Clinical study of etomidate and propofol mixture in pediatric induction of general anesthesia
依托咪酯与丙泊酚混合液在小儿全身麻醉诱导中的临床研究

摘要

目的 探究小儿全身麻醉诱导中应用依托咪酯与丙泊酚混合液的临床效果。方法 回顾本院2021.6-2022.6之间全身麻醉诱导干预患儿90例进行研究，其中使用依托咪酯与丙泊酚混合液的视为联合组（EP组），单独使用依托咪酯、丙泊酚视为依托咪酯组（E组）、丙泊酚组（P组），以双盲法各入组30例，对比三组四点口述分级评分法VRS-4、Blitt分级、Ricker镇静-躁动评分(SAS)的相关数据。结果 三组疼痛从轻到重的程度依次为E组>EP组>P组，P<0.05。三组肌颤从轻到重的程度依次为P组>EP组>E组。三组镇静-躁动从优到差的顺序依次是EP组>E组>P组。（P<0.05）。结论 全身麻醉诱导中，依托咪酯与丙泊酚混合液可稳定患儿的血压、减少患儿体征的波动，肌颤躁动、注射痛的比例少，无论是单独应用依托咪酯还是丙泊酚，其效果都远不如依托咪酯与丙泊酚混合液产生的麻醉安全效果，混合液诱导形式具有推广意义。

Abstract

Objective To explore the clinical effect of etomidate and propofol mixture in the induction of general anesthesia in children.
Methods Review 90 children with general anesthesia induction intervention between 2021.6-2022.6, using etomidide and propofol mixture as combination group (group EP), etomidate and propofol group (group E) and propofol (group P), study 30 patients in double-blind method and compare the data of VRS-4, Blitt grade, Ricker sedation-agitation score (SAS).
Results Three mild to severe pain groups were group E>EP group>P group, and P<0.05. The degree of muscle fibrillation from light to heavy in the three groups was group P>EP>E. The order of sedation-agitation was EP>E>P (P<0.05).
Conclusion   general anesthesia induction, etomidate and propofol mixture can stabilize children with blood pressure, reduce the fluctuation of signs, muscle fibrillation agitation, injection pain, whether used alone etomimidate or propofol, its effect is far less than etomimidate and propofol mixture anesthesia safety effect, mixture induction form has promotion significance.