Study on the treatment of lung injury by sivellex sodium
西维来司钠治疗放射性肺损伤研究

摘要

目的 分析放射性肺损伤采取西维来司钠治疗产生的实际意义。方法 实验对象：27例放射性肺损伤患者。实验时间：2019年4月至2021年4 月。实验分组方式：随机数表分组方式。实验分组类别：对照组实施基础治疗，为13例患者。观察组实施西维来司钠治疗，为13例患者。实验根本目的：对比两种治疗前、后患者炎症因子水平、对比两种治疗后总有效率、对比两种治疗前、后血气指标。对比两种治疗前、后血清转移生长因子-B1。结果 观察组治疗总有效率显著高于对照组，观察组治疗后IL-6、CRP水平显著较低，IL-10水平显著较高，观察组治疗后PaO2、PaO2/FiO2显著增高，PaCo2显著降低，观察组治疗后血清转移生长因子-B1浓度显著降低，（P<0.05）为差异显著，有统计学意义。结论 放射性肺损伤采取西维来司钠治疗能够起到较强抗炎效果，改善血气水平，降低机体内血清转移生长因子-B1浓度，有效阻碍放射性肺损伤发生，治疗效果较显著，值得临床重视。

Abstract

Objective To analyze the practical significance of sivellex sodium in the treatment of radioactive lung injury.
Methods Experimental objects: 27 patients with lung injury caused by radiation. Experiment time: From April 2019 to April 2021. Experimental grouping method: random table grouping method. Experimental group: 13 patients in the control group received basic treatment. Observation group was treated with sivellex sodium, including 13 patients. The basic purpose of the experiment: to compare the levels of inflammatory factors in patients before and after two kinds of treatment, to compare the total effective rate after two kinds of treatment, and to compare the blood gas indexes before and after two kinds of treatment. Serum transfer growth factor B1 was compared before and after treatment.
Results The total effective rate in the observation group was significantly higher than that in the control group, il-6 and CRP levels were significantly lower and IL-10 levels were significantly higher in the observation group, PaO2 and PaO2/FiO2 were significantly increased and PaCo2 was significantly decreased in the observation group, and serum transfer growth fact-B1 concentration was significantly decreased in the observation group after treatment. (P<0.05) was statistically significant.
Conclusion   The treatment of radioactive lung injury with sivelax sodium can play a strong anti-inflammatory effect, improve blood gas level, reduce the concentration of serum transfer growth factor B1 in the body, effectively block the occurrence of radioactive lung injury, the treatment effect is significant, worthy of clinical attention.