Clinical Study of Enteral Nutrition Support for Severe Acute Pancreatitis
肠内营养支持治疗重症急性胰腺炎的临床研究

摘要

目的：探究肠内营养支持治疗重症急性胰腺炎的临床应用价值。方法：于我院消化内科选取74例患者作为本次实验的研究对象，据调查均符合重症急性胰腺炎诊断标准，并在其入组后按照随机数表法分配为对照组和观察组，每组37例患者，使用不同的营养支持方式，其中对照组使用场外营养支持治疗，观察组使用肠内营养支持治疗，对比两种不同营养支持治疗方式的临床应用效果。结果：在入院治疗前，两组患者的血细胞因子水平变化、APACHE II评分之间无统计学意义，（P＞0.05）。在营养支持治疗1周、2周后，两组患者的CRP、TNF-α、IL-1β、IL-6等血细胞因子指标均得到了明显改善，且使用肠内营养支持治疗的观察组改善情况更加明显，（P＜0.05）。其次，观察组患者在入院治疗后2周，其APACHE II评分为（5.52±3.74）分，对照组为（8.64±2.53）分，数据间差异较大，存在统计学意义，（P＜0.05）。结论：对重症急性胰腺炎患者使用肠内营养支持治疗效果更佳，能够有效提升患者预后营养状况。

Abstract

Objective: To explore the clinical value of enteral nutritional support for severe acute pancreatitis.
Methods: 74 patients were selected as the research object in this experiment in the Department of Gastroenterology of our hospital. According to the investigation, they all met the diagnostic criteria for severe acute pancreatitis, and were assigned to the control group and the observation group according to the random number table method The 37 patients in the group used different nutritional support methods, of which the control group used off-site nutritional support treatment, and the observation group used enteral nutritional support treatment to compare the clinical application effects of two different nutritional support treatment methods.
Results: Before admission to the hospital, there was no statistically significant difference in blood cytokine level and APACHE II score between the two groups (P> 0.05). After 1 week and 2 weeks of nutritional support treatment, the CRP, TNF-α, IL-1β, IL-6 and other blood cytokine indicators of the two groups of patients were significantly improved, and the observation group using enteral nutritional support treatment improved More obvious, (P <0.05). Second, patients in the observation group had an APACHE II score of (5.52 ± 3.74) points and (8.64 ± 2.53) points in the control group 2 weeks after admission to hospital.
Conclusion  : The use of enteral nutrition support therapy for patients with severe acute pancreatitis is better and can effectively improve the prognosis of patients.