Clinical observation of Niuhuang Jiedu soft capsules combined with levofloxacin in the treatment of acute conjunctivitis
牛黄解毒软胶囊联合左氧氟沙星治疗风热壅目型急性结膜炎的临床观察

摘要

目的 评估牛黄解毒软胶囊联合左氧氟沙星滴眼液在治疗风热壅目型急性结膜炎患者中的临床疗效。方法 本研究共纳入72例急性结膜炎患者，并将其分为对照组和实验组。两组患者在性别、年龄、发病部位和病程等基线资料上差异无统计学意义（P>0.05）。对照组患者仅接受左氧氟沙星滴眼液治疗，而实验组患者在左氧氟沙星滴眼液治疗的基础上，加用牛黄解毒软胶囊，治疗周期为7天。通过对比治疗前后的症状，如眼刺痛、眼痒、分泌物、结膜充血和白睛红肿等、血清炎症因子和泪液指标，来评估临床疗效。结果 治疗结束后，实验组的临床有效率高达97.2%，显著高于对照组的86.2%，卡方检验表明差异具有统计学意义（P<0.05）。两组患者在治疗后各项症状均有改善，其中实验组在除结膜充血外的其他症状上，与对照组相比均显著降低，差异具有统计学意义（P<0.01）。此外，治疗后实验组患者的血清炎症因子（IL-8和TNF-α）及泪液指标（HA和IgE）均显著低于对照组，差异具有统计学意义（P<0.01）。结论 牛黄解毒软胶囊与左氧氟沙星滴眼液联合治疗急性结膜炎，临床疗效显著。

Abstract

Objective To evaluate the clinical efficacy of Niuhuang Jiedu soft capsules combined with levofloxacin eye drops in the treatment of patients with acute conjunctivitis.
Methods A total of 72 patients with acute conjunctivitis were included in this study and divided into a control group and an experimental group. There were no statistically significant differences in baseline data such as gender, age, location of disease onset, and duration of illness between the two groups (P>0.05). Patients in the control group were treated only with levofloxacin eye drops, while patients in the experimental group were additionally administered Niuhuang Jiedu soft capsules on top of the levofloxacin eye drops treatment, with a treatment duration of 7 days. The clinical efficacy was assessed by comparing the symptoms before and after treatment, such as pharyngeal pain, eye irritation, eye itching, corneal secretion, conjunctival congestion, and white eye swelling, as well as serum inflammatory factors and tear indicators.
Results After the treatment, the clinical effective rate of the experimental group reached 97.2%, which was significantly higher than the 86.2% of the control group. The chi-square test indicated that the difference was statistically significant (P<0.05). Both groups showed improvement in symptoms after treatment, with the experimental group showing a significant reduction in all symptoms except conjunctival congestion when compared to the control group, and the differences were statistically significant (P<0.01). Moreover, the serum inflammatory factors (IL-8 and TNF-α) and tear indicators (HA and IgE) in the experimental group were significantly lower than those in the control group after treatment, with statistically significant differences (P<0.01).
Conclusion   The combined treatment of Niuhuang Jiedu soft capsules and levofloxacin eye drops for acute conjunctivitis demonstrates significant clinical efficacy.