摘要
本文综述了智能药物输送系统，探讨了该系统通过技术创新实现药物精准、高效、安全输送的核心价值。研究回顾了药物输送技术的历史演进，特别是纳米技术和靶向识别技术的突破性进展，以及远程控制与实时监测技术在该领域的创新应用。在应用领域方面，文章详细分析了智能药物输送系统在癌症治疗、慢性病管理、紧急救援等多个关键医疗领域的广泛应用，展示了其在实际医疗实践中的巨大潜力和优势。同时，也直面当前研究面临的挑战，包括技术瓶颈的突破、法规政策的完善、伦理道德的考量，以及跨学科合作的需求等，为未来的研究方向提供了宝贵的参考。最后，文章展望了智能药物输送系统未来的发展趋势，指出了技术创新的主要方向、临床应用的广阔前景，以及人才培养和国际合作对于推动该领域持续发展的重要性。通过本文的综述，旨在为智能药物输送系统的进一步研究和应用提供坚实的理论基础和实践指导。
关键词： 智能药物输送系统；现代医疗；精准医疗
Abstract
This paper reviews the intelligent drug delivery system and explores the core value of the system in achieving accurate, efficient and safe drug delivery through technological innovation. The study reviews the historical evolution of drug delivery technology, especially the breakthrough progress of nanotechnology and targeted recognition technology, as well as the innovative application of remote control and real-time monitoring technology in this field. In terms of application fields, the article analyzes in detail the wide application of intelligent drug delivery systems in multiple key medical fields such as cancer treatment, chronic disease management, and emergency rescue, demonstrating its great potential and advantages in actual medical practice. At the same time, it also faces the challenges faced by current research, including breakthroughs in technical bottlenecks, improvements in regulations and policies, ethical considerations, and the need for interdisciplinary cooperation, providing valuable references for future research directions. Finally, the article looks forward to the future development trend of intelligent drug delivery systems, pointing out the main directions of technological innovation, the broad prospects for clinical applications, and the importance of talent training and international cooperation in promoting the sustainable development of this field. Through this review, it aims to provide a solid theoretical foundation and practical guidance for further research and application of intelligent drug delivery systems.
Key words： Intelligent drug delivery system; Modern medicine; Precision medicine
参考文献 References
[1] Li, Jinhua, et al. "Biohybrid micro-and nanorobots for intelligent drug delivery." Cyborg and Bionic Systems (2022).
[2] Yang, Xin, et al. "Multiple stimuli‐responsive MXene‐based hydrogel as intelligent drug delivery carriers for deep chronic wound healing." Small 18.5 (2022): 2104368.
[3] Bami, Marzieh Sajadi, et al. "pH-responsive drug delivery systems as intelligent carriers for targeted drug therapy: Brief history, properties, synthesis, mechanism and application." Journal of Drug Delivery Science and Technology 70 (2022): 102987.
[4] Tan, Minhong, et al. "Recent advances in intelligent wearable medical devices integrating biosensing and drug delivery." Advanced Materials 34.27 (2022): 2108491.
[5] Li, Minghua, et al. "An intelligent responsive macrophage cell membrane-camouflaged mesoporous silicon nanorod drug delivery system for precise targeted therapy of tumors." Journal of Nanobiotechnology 19 (2021): 1-16.
[6] Wang, Xiaoyou, et al. "Smart drug delivery systems for precise cancer therapy." Acta Pharmaceutica Sinica B 12.11 (2022): 4098-4121.
[7] Adepu, Shivakalyani, and Seeram Ramakrishna. "Controlled drug delivery systems: current status and future directions." Molecules 26.19 (2021): 5905.
[8] He, Sheng, Leon G. Leanse, and Yanfang Feng. "Artificial intelligence and machine learning assisted drug delivery for effective treatment of infectious diseases." Advanced drug delivery reviews 178 (2021): 113922.
[9] He, Sheng, Leon G. Leanse, and Yanfang Feng. "Artificial intelligence and machine learning assisted drug delivery for effective treatment of infectious diseases." Advanced drug delivery reviews 178 (2021): 113922.
[10] Khan, Md Ishak, et al. "Recent progress in nanostructured smart drug delivery systems for cancer therapy: a review." ACS Applied Bio Materials 5.3 (2022): 971-1012.
[11] Li, Lixian, et al. "Progress on Preparation of pH/Temperature‐Sensitive Intelligent Hydrogels and Applications in Target Transport and Controlled Release of Drugs." International Journal of Polymer Science 2021.1 (2021): 1340538.
[12] Gao, Jingjing, et al. "The future of drug delivery." Chemistry of Materials 35.2 (2023): 359-363.
[13] Barkat, Md A., et al. "Lipid-based nanosystem as intelligent carriers for versatile drug delivery applications." Current pharmaceutical design 26.11 (2020): 1167-1180.
[14] Zhou, Lei, et al. "Smart nanosized drug delivery systems inducing immunogenic cell death for combination with cancer immunotherapy." Accounts of Chemical Research 53.9 (2020): 1761-1772.
[15] 左佑.小干扰RNA的纳米药物输送系统及其用于癌症治疗的研究[J].中国科技纵横, 2020.
[16] 陈华超.智能纳米递药系统的构建及其在药物可控释放中的应用[D].南京大学,2015.
[17] 郑伟斌,张博雅,殷晓辰,等.基于二氧化硅纳米粒子的抗肿瘤药物递送系统研究进展[J].肿瘤防治研究, 2020, 47(2):6.
[18] Umme Hani.新型药物传递系统治疗宫颈癌的研究现状:综述[J].[2024-08-21].
[19] 沈重重.纳米疗法癌症治疗最新应用[J].健康之友, 2018.
[20] 姚舒婷.智能纳米凝胶药物输送系统的构建及抗肿瘤性能研究[D].浙江理工大学,2021.
[21] 韩鑫.基于杂交链式反应构建癌症标志物检测和癌细胞给药平台[D].北京化工大学,2023.
[22] 周珠贤,申有青,赵宇亮.抗肿瘤纳米药物递送系统的研究现状与展望[J].中国基础科学, 2022(1):12.
[23] 刘霞.新疗法有助免疫系统根除脑肿瘤[J].老同志之友:下半月, 2023(9):47-47.
[24] 林绪月,蔡笃雄.LHPP在消化系统肿瘤中的研究进展[J].胃肠病学和肝病学杂志, 2023, 32(11):1311-1315.
[25] Lin, Xueqi, et al. "Intellective and stimuli-responsive drug delivery systems in eyes." International Journal of Pharmaceutics 602 (2021): 120591.
[26] Zhang, Jinyuan, et al. "Wearable glucose monitoring and implantable drug delivery systems for diabetes management." Advanced Healthcare Materials 10.17 (2021): 2100194.