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Open Access Article

International Medical Research Frontier. 2024; 8: (1) ; 35-41 ; DOI: 10.12208/j.imrf.20240009.

Progress for clinical pharmacology and application of bupropion
安非他酮临床药理及应用新进展

作者: 黄璐璐1,2,3, 于洋4, 韩晓雨1,2,3, 肖云1,2,3, 张永杰5, 刘方兰2, 何佳珂1,2,5,6 *

1 南昌大学第二附属医院药学部 江西南昌
2 南昌大学临床药理研究所 江西南昌
3 南昌大学药学院 江西南昌

4 南昌大学第二附属医院医务处 江西南昌

5 中国药科大学基础医学院和临床药学院 江苏南京

6 南昌县人民医院药剂科 江西南昌

*通讯作者: 何佳珂,单位: 南昌县人民医院药剂科 江西南昌;

发布时间: 2024-06-29 总浏览量: 543

摘要

作为新型氨基酮类抗抑郁药,安非他酮通过阻滞多巴胺和去甲肾上腺素再摄取以发挥疗效。安非他酮体内过程复杂,CYP2B6、羰基还原酶、UGT2B7和UGT1A等参与其体内立体选择性代谢,影响临床疗效的发挥。该文通过查阅国内外相关文献,就安非他酮药理作用机制、体内过程、相互作用、抗抑郁、戒除烟瘾以及减肥治疗的有效性和安全性做一综述,以期为临床安全、合理、有效用药提供参考。

关键词: 安非他酮;作用机制;体内过程;抗抑郁;减肥;戒烟

Abstract

Bupropion is an aminoketone antidepressant, which exerts its effects mainly by inhibiting dopamine and norepinephrine. Bupropion is stereoselective metabolized by CYP2B6, carbonyl reductase, UGT2B7 and UGT1A in vivo which affect its clinical efficacy. Based on published researches, a systematic review was conducted focusing mainly on the pharmacological mechanisms, in-vivo disposition, drug-drug interaction, safety, and effectiveness of bupropion in antidepressant therapy, weight loss and smoking cessation, providing guidelines for clinical practice.

Key words: Bupropion; Mechanism; ADME; Antidepressant; Weight loss; Smoking cessation

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引用本文

黄璐璐, 于洋, 韩晓雨, 肖云, 张永杰, 刘方兰, 何佳珂, 安非他酮临床药理及应用新进展[J]. 国际医药研究前沿, 2024; 8: (1) : 35-41.