Comparative analysis of the clinical efficacy of aripiprazole and clozapine in schizophrenia
阿立哌唑与氯氮平治疗精神分裂症的临床疗效对比分析

摘要

目的 比较阿立哌唑与氯氮平治疗精神分裂症的临床疗效。方法 选择本院精神科收治的精神分裂症患者进行研究，共计80例，收治时间为2020年6月至2021年12月。采用计算机抽号方式随机分组，分A组和B组，每组各40例患者。A组使用阿立哌唑治疗，B组使用氯氮平治疗。比较两组患者临床疗效、用药不良反应发生率。结果 两组临床有效率比较（P>0.05）。A组用药不良反应发生率2.50%，显著低于B组（P<0.05）。治疗后，A组GPT、GOT水平分别为（32.08±3.85）u/L、（32.68±4.52）u/L，低于B组（P<0.05）。治疗后，两组SSPI、PANSS得分比较（P>0.05）。结论 精神分裂症患者应用阿立哌唑与氯氮平治疗均可取得一定的疗效，但氯氮平用药不良反应更高，对人体肝功能损伤更为严重，建议首选阿立哌唑。

Abstract

Objective To compare the clinical efficacy of aripiprazole and clozapine in schizophrenia.
Methods A total of 80 schizophrenia patients admitted to the psychiatric department of our hospital were studied from June 2020 to December 2021. Randomization was performed by groups A and B, with 40 patients in each group. Group A was treated with aripiprazole and Group B with clozapine. The clinical efficacy and the incidence of adverse drug effects were compared between the two groups.
Results The two groups were compared clinically efficiently (P> 0.05). The incidence of adverse drug reactions in group A was 2.50%, which was significantly lower than that in group B (P <0.05). After treatment, the GPT and GOT levels in group A were (32.08 ± 3.85) u / L and (32.68 ± 4.52) u / L, respectively, which were lower than those in group B (P <0.05). After treatment, the SSPI and PANSS scores were compared between the two groups (P> 0.05).
Conclusion   Both aripiprazole and clozapine have higher adve