To compare the clinical effects of omeprazole and pantoprazole combined with amoxicillin in patientswith gastric ulcer
对比胃溃疡患者应用奥美拉唑与泮托拉唑分别联合阿莫西林治疗的临床效果

摘要

目的 对比胃溃疡患者应用奥美拉唑与泮托拉唑分别联合阿莫西林治疗的临床效果。方法 本医院所有患者均采用计算机随机分组，60例胃溃疡患者被平均分为观察组(n=30)和对照组（n=30），前者应用泮托拉唑联合阿莫西林治疗，后者应用奥美拉唑联合阿莫西林治疗，实施时间为2021年1月至2022年1月。将两组患者的临床疗效、炎症指标进行比较。结果 在总有效率控制方面，两组数据差异很大，观察组、对照组分别为96.67%、86.67%， 两组差异在统计学上较为显著（P＜0.05）；观察组与对照组相比，治疗前，将其PCT、CRP、IL-6、IL-1水平数据进行分析，得出两组的数据较为相似（P＞0.05）；治疗1个疗程后，前者四项指标显著下降（P＜0.05）。结论 在胃溃疡患者的临床治疗选择中，与奥美拉唑联合阿莫西林治疗相比，泮托拉唑联合阿莫西林治疗更能提升临床疗效，改善炎症水平，值得临床应用。

Abstract

Objective To compare the clinical effects of omeprazole and pantoprazole combined with amoxicillin in patients with gastric ulcer.
Methods All patients in our hospital were randomly divided into two groups by computer. Sixty patients with gastric ulcer were equally divided into the observation group (n=30) and the control group (n=30). The former was treated with pantoprazole combined with amoxicillin, and the latter was treated with omeprazole combined with amoxicillin from January 2021 to January 2022. The clinical efficacy and inflammatory indicators of the two groups were compared.
Results In terms of total effective rate control, there was a great difference between the two groups, 96.67% in the observation group and 86.67% in the control group, which was statistically significant (P<0.05); Compared with the control group, the levels of PCT, CRP, IL-6 and IL-1 in the observation group were analyzed before treatment, and the data in the two groups were similar (P>0.05); After one course of treatment, the four indexes of the former decreased significantly (P<0.05).
Conclusion   Compared with omeprazole combined with amoxicillin, pantoprazole combined with amoxicillin can improve the clinical efficacy and inflammation level of patients with gastric ulcer, which is worthy of clinical application.