Evaluation of hemoperfusion combined with hemodialysis in uremic patients
血液灌流联合血液透析治疗尿毒症患者皮肤瘙痒对其症状的改善评价

摘要

目的 探讨将血液灌流与血液透析联合运用于尿毒症皮肤瘙痒患者中的效果。方法 选取66例2021年1月-2022年6月本院接受治疗的尿毒症皮肤瘙痒患者进行研究，经随机数字表法分组。对照组（33例），观察组（33例），分析两组肾功能指标、钙磷代谢指标、皮肤瘙痒程度。结果 观察组治疗后的BUN、Scr、PTH水平分别为（8.87±1.12）mmol/L、（149.86±15.24）μmol/L、（120.24±11.96）ng/mL，均较对照组的（15.42±2.19）mmol/L、（263.54±21.02）μmol/L、（179.35±15.24）ng/mL低；治疗后，观察组的血清磷水平、皮肤瘙痒评分分别为（1.45±0.21）mmol/L、（3.14±0.31）分，较对照组的（2.27±0.33）mmol/L、（5.26±0.65）分低，血清钙水平为（2.69±0.47）mmol/L，较对照组的（1.95±0.38）mmol/L高；均P＜0.05。结论 以血液灌流＋血液透析的方式对尿毒症皮肤瘙痒患者进行治疗，能够在一定程度上改善其皮肤瘙痒症状，同时促进其肾功能恢复，调节钙磷代谢。

Abstract

Objective: To explore the effect of combining hemoperfusion and hemodialysis in patients with uremic pruritus.
Methods: 66 uremic pruritus patients treated in our hospital from January 2021 to June 2022 were studied and grouped by random numbers. In the control group (33 cases) and the observation group (33 cases), the renal function index, calcium and phosphorus metabolism index and skin pruritus degree were analyzed.
Results: The treated BUN, Scr, and PTH levels in the observation group were (8.87 ± 1.12) mmol/L, (149.86 ± 15.24) μmol/L, and (120.24 ± 11.96) ng/mL, respectively, All these were lower than the (15.42 ± 2.19) mmol/L, (263.54 ± 21.02) μmol/L, and (179.35 ± 15.24) ng/mL of the control group; post-treatment, The serum phosphorus levels and skin pruritus scores of the observed group were (1.45 ± 0.21) mmol/L and (3.14 ± 0.31) scores, respectively, Compared with the (2.27 ± 0.33) mmol/L and (5.26 ± 0.65) scores of the control group, Serum calcium level was (2.69 ± 0.47) mmol/L, The mmol/L was higher than that of the control group (1.95 ± 0.38); All cases were P <0.05.
Conclusion  : It can improve their skin itching symptoms, promote their renal function recovery, and regulate calcium and phosphorus metabolism.