Protective effect of silybin on Alzheimer's disease animal model
水飞蓟宾对阿尔茨海默病动物模型的保护作用研究

摘要

目的 研究水飞蓟宾对阿尔茨海默病动物模型的保护作用。方法 将购买的90只实验小鼠制作为阿尔茨海默病动物模型，随机分为三组，分别为实验1组、实验2组与对比组，每组30只，对比组造模成功后给予生理盐水，实验1组给予低剂量水飞蓟宾，实验2组给予高剂量水飞蓟宾，观察三组自发反应交替率和海马组织炎性因子水平。结果 实验1、2组的总进臂次数、自发反应交替率高于对比组，白细胞介素-4（IL-4）、白细胞介素-6（IL-6）低于对比组（P＜0.05）；实验2组总进臂次数、自发反应交替率高于实验1组，IL-4、IL-6低于实验1组（P＜0.05）。结论 水飞蓟宾对阿尔茨海默病动物模型有良好的保护作用。

Abstract

Objective To study the protective effect of silybin on Alzheimer's disease animal model.
Methods the purchased 90 experimental mice were made into the animal model of Alzheimer's disease, and were randomly divided into three groups, namely, experimental group 1, experimental group 2 and control group, with 30 mice in each group. The control group was given normal saline after the success of modeling, experimental group 1 was given low-dose silybin, and experimental group 2 was given high-dose silybin. The spontaneous reaction alterna- tion rate and the level of inflammatory factors in the hippocampus of the three groups were observed.
Results the total number of arm entry and spontaneous reaction alternation rate in experimental group 1 and 2 were higher than those in the control group, and the levels of interleukin-4 (IL-4) and interleukin-6 (IL-6) were lower than those in the control group (P<0.05); The total number of arm entry and spontaneous reaction alternation rate in experimental group 2 were higher than those in experimental group 1, and IL-4 and IL-6 were lower than those in experimental group 1 (P<0.05).
Conclusion   silybin has a good protective effect on the animal model of Alzheimer's disease.