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International medical research frontier. 2018; 2: (1) 1; DOI:10.26855/j.imrf.20180001.

Efficacy of cisplatin thermochemotherapy for patients with ovarian cancer and the impact of serum FSH, LH, E2 levels
卵巢癌患者行顺铂热化疗的疗效及对血清FSH、LH、E2水平的影响

作者: 张晓英*

陕西省咸阳市中心医院妇科

*通讯作者:张晓英,单位:陕西省咸阳市中心医院妇科;

引用本文: 张晓英. 卵巢癌患者行顺铂热化疗的疗效及对血清FSH、LH、E2水平的影响. 国际医药研究前沿, 2018, 2(1)
Published: 2018-06-12

摘要

【摘要】目的:探讨卵巢癌患者行顺铂热化疗的疗效及对患者血清FSH、LH、E2水平的影响。方法:将本院收治的70例卵巢癌患者随机分为两组(n=35),对照组采用常规顺铂化疗方案,观察组实施顺铂热化疗,对比两组的治疗效果及治疗前后的血清FSH、LH、E2水平变化。结果:两组治疗后的FSH、LH水平均较治疗前明显降低,E2水平较治疗前明显升高,且观察组的FSH、LH水平明显高于对照组,E2水平明显低于对照组(P<0.05)。观察组治疗后的PI3K、AKT、CA125水平均显著低于对照组(P<0.05)。观察组的治疗总有效率为91.43%,显著高于对照组的71.43%(P<0.05)。两组的不良反应发生率比较无显著性差异(P>0.05)。结论:顺铂热化疗治疗卵巢癌可有效改善患者的卵巢功能,降低凋亡相关调控功能因子表达,提高临床疗效。

关键词: 【关键词】卵巢癌;顺铂热化疗;卵巢功能;激素

Abstract

[Abstract] Objective: To investigate the effect of cisplatin thermochemotherapy for patients with ovarian cancer and the impact of serum FSH, LH, E2 levels.
Methods: 70 patients with ovarian cancer were randomly divided into two groups (n=35). The control group received conventional cisplatin chemotherapy, and the observation group received cisplatin thermochemotherapy. Then compared the treatment effect and the serum FSH, LH, E2 levels changes before and after treatment.
Results: The levels of FSH and LH in both groups were significantly lower than those before treatment, the level of E2 was significantly higher than that before treatment, and the levels of FSH and LH in the observation group were significantly higher than control group (P<0.05) ). The levels of PI3K, AKT and CA125 in the observation group were significantly lower than control group (P<0.05). The total effective rate of the observation group was 91.43%, which was significantly higher than control group (71.43%, P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).
Conclusion  : Cisplatin chemotherapy in the treatment of ovarian cancer patients can effectively improve ovarian function, reduce the expression of apoptosis related regulatory factors, improve clinical efficacy.

Key words: [Key words] Ovarian cancer; Cisplatin thermochemotherapy; Ovarian function; Hormones

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