International medical research frontier. 2018; 2: (1) 1; DOI:10.12208/j.imrf.20180001.
[Abstract] Objective: To investigate the effect of cisplatin thermochemotherapy for patients with ovarian cancer and the impact of serum FSH, LH, E2 levels. Methods: 70 patients with ovarian cancer were randomly divided into two groups (n=35). The control group received conventional cisplatin chemotherapy, and the observation group received cisplatin thermochemotherapy. Then compared the treatment effect and the serum FSH, LH, E2 levels changes before and after treatment. Results: The levels of FSH and LH in both groups were significantly lower than those before treatment, the level of E2 was significantly higher than that before treatment, and the levels of FSH and LH in the observation group were significantly higher than control group (P<0.05) ). The levels of PI3K, AKT and CA125 in the observation group were significantly lower than control group (P<0.05). The total effective rate of the observation group was 91.43%, which was significantly higher than control group (71.43%, P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion : Cisplatin chemotherapy in the treatment of ovarian cancer patients can effectively improve ovarian function, reduce the expression of apoptosis related regulatory factors, improve clinical efficacy.