International medical research frontier. 2017; 1: (1) 1; DOI:10.26855/j.imrf.20170001.
[Abstract] Objective: To investigate the clinical efficacy of anti-oxidant free radical therapy to reduce the frequency of seizures and epileptiform discharge. Methods: 98 epilepsy patients were divided into two groups by random number table (n=49). The control group accepted basic antiepileptic treatment, and the observation group increased vitamin E and Vitamin C. Then observed the seizure frequency and epileptiform discharge situation before and after treatment of two groups. Results: The total effective rate of seizure frequency in observation group was 93.88%, which was significantly higher than 65.31% of control group (P<0.05) . The total effective rate of epileptiform discharge was 89.80% in observation group and 71.43% in control group, there was a significant difference between the two groups (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The delayed memory, attentional score and MOCA total scores in the observation group were significantly higher than those in the control group (P<0.05). Conclusion : The anti-oxygen free radical adjuvant treatment of epilepsy can effectively reduce the frequency of seizures and epileptiform discharges, and also help to improve the cognitive function of patients. It has exact clinical efficacy.